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Happy New Year 2018





Publication : Plasmodesmata architecture

Toutes les actualités



Frederic Domergue and Franziska Dittrich, together with Magdalena Miklaszewska and Antoni Banas from the University of Gdansk in Poland published a paper in Applied Microbiology and Biotechnology entitled "Wax synthase MhWS2 from Marinobacter hydrocarbonoclasticus : substrate specificity and biotechnological potential for wax ester production" (DOI : 10.1007/s00253-018-8878-8)." ICON survives...

Miklaszewska M., Dittrich-Domergue F., Banaś A. and Domergue F. (2018) Wax synthase MhWS2 from Marinobacter hydrocarbonoclasticus : substrate specificity and biotechnological potential for wax ester production.
Accepted in Applied Microbiology and Biotechnology


[February, 9 2018] Thorsten Nuernberger and his post-doc fellow Isabel Albert from the University of Tubiengen, Germany came to give a seminar on "Plant immunogenic and virulence functions of microbial NLP cytolysins" invited by Sébastien Mongrand and the FR BIE.
Sébastien and Adiilah Mamode-Cassim colloborated with Thorsten and Isabell for the paper published last year in Science on the role of sphingolipid as receptors of toxin NLP. Thank you for the visit and all the nice discussions !


[February 14, 2018] Marina Le Guedard and Eric Testet have contributed to a publication in Microbial Cell. This study, realized in collaboration with Maxence de Taffin de Tilques et al., IBGC UMR 5095 in Bordeaux, identifies a potential therapeutic target for the treatment of Barth syndrom disease.

Collaboration with the University of Oxford Brookes

[February 9, 2018] Reticulons are integral ER membrane proteins characterised by a reticulon homology domain comprising four transmembrane domains which results in the proteins sitting in the membrane in a W-topology. We report on a novel subgroup of reticulons with an extended N-terminal domain. Using high resolution confocal microscopy we show that reticulon 20 is located in a unique punctate pattern on the ER membrane. Its closest homologue reticulon 19 labels the whole ER. Other than demonstrated for the other members of the reticulon protein family RTN20 and 19 do not display ER constriction phenotypes on over expression.
We show that mutants in RTN20 or RTN19 display a significant change in sterol composition in roots indicating a role in lipid biosynthesis. A third homologue in this family -3BETAHSD/D1- is unexpectedly localised to ER exit sites and also induces a modification in sterol levels.

Kriechbaumer V, Maneta-Peyret L, Fouillen L, Botchway SW, Upson J, Hughes L, Richardson J, Kittelmann M, Moreau P, Hawes C. (2018). The odd one out : Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid biosynthesis. Scientific Reports, 8:2310 | DOI:10.1038/s41598-018-20840-0.