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Physiological role of long-chain polyunsaturated fatty-acids in membranes of the model pico-alga Ostreococcus tauri.

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Group leader : Florence Corellou, researcher CNRS

contact :
phone : 00 33 5 57 12 25 67
e-mail : florence.corellou@u-bordeaux.fr

Florence Corellou obtained her PhD in 2000 at the Roscoff Marine Station. (University of Rennes1). She held a post-doctoral position at the Marine Biological Association, Plymouth, UK (2000-2001, Cancer Research Association ARC felowship) and then at the Department of Plant Genetics of the Flanders (VIB), Ghent, Belgium (2001-2002, EMBO Long term fellowship). She obtained a CNRS research position in 2001 and joined the Banyuls Oceanologic Laboratory (CNRS-UPMC), France in 2002.She moved to Bordeaux end of 2013.Since 2002 she is working on the minimal photosynthetic organism Ostreococcus tauri she greatly contributed to implement as a model system.
From 1996 to 2005 her research interests focused on cell-cycle molecular regulations (in the zygote of the macrolaga Fucus, briefly in higher plants and in the microalgae O. tauri) and how it is related to the control of polarization (fucus zygotes) or to the circadian control (Ostreococcus tauri). From 2005 to 2013 she focused her research on the molecular work of circadian clock in O. tauri. Since 2013, she is developing a new research project that is taking advantage of O. tauri minimalist features and ancestral position in the green lineage to gain insight in lipid metabolism and LC-PUFA functions in microalgae.

Group members : F. Corellou (CR), J. Joubès (MC), F. Domergue (CR), K. Tuphile (TR)

My current research interests are related to lipid metabolism in the marine green pico-alga Ostreococcus tauri. Polyunsaturated Fatty Acids (PUFAs) biosynthetis and regulation of PUFAs content in membranes lipids including signaling of cues governing changes in PUFAs composition are under focus. I am working on O. tauri since 2002 and supported the implementation of O. tauri as model system especially by setting up genetic transformation. O. tauri is a powerfull model system for which important genomic resources, genetic manipulation, including gene replacement by homologous recombination have been implemented in the last decade. O. tauri has the advantage of being extremely simple and compact (less than 8000 genes, one of each organelle) and is yet the only microlagal transformable model system that efficiently produces the vital and highly valuable omega-3 Fatty Acid DHA (Docoshexaenoic acid).

Ostreococcus tauri, Center dividing cell, dividing chloroplast and mitochondria

Marine microalgae are the primary producers of LC-PUFAs which are vital for animal health and accumulate in fish-oils through the food-web. Marine microalgae have been identified as a sustainable alternative for LC-PUFAs production. Knowledge about PUFAs biosynthetic pathways and accumulation in oils is required to rationalize the use of microalgae for biotechnological applications. The apprehension of physiological functions of PUFAs, which remain poorly understood, meets both fundamental and applied issues. Why marine microalgae display such a wide and specific panel of PUFAs and to which extent PUFAs content are involved in the regulation of membrane functions such as photosynthesis, channel regulation and signaling of membrane states remains to be determined. We are deciphering the pathways involved in PUFAs synthesis and in the incorporation in structural and storage lipids in response to various environmental cues. Major physiological outputs considered are membrane fluidity and photosynthesis efficiency.

Sélection d’articles :

  • Degraeve-Guilbault C, Bréhélin C, Haslam R, Sayanova O, Marie-Luce G, Jouhet J, Corellou F. Glycerolipid Characterization and Nutrient Deprivation-Associated Changes in the Green Picoalga Ostreococcus tauri. Plant Physiol. 2017 Apr ;173(4):2060-2080.
  • O’Neill JS, van Ooijen G, Dixon LE, Troein C, Corellou F, Bouget FY, Reddy AB, Millar AJ. Circadian rhythms persist without transcription in a eukaryote. Nature. 2011 Jan 27 ;469(7331):554-8.
  • Djouani-Tahri el-B, Christie JM, Sanchez-Ferandin S, Sanchez F, Bouget FY, Corellou F. A eukaryotic LOV-histidine kinase with circadian clock function in the picoalga Ostreococcus. Plant J. 2011 Feb ;65(4):578-88.
  • Moulager M, Corellou F, Vergé V, Escande ML, Bouget FY. Integration of light signals by the retinoblastoma pathway in the control of S phase entry in the picophytoplanktonic cell Ostreococcus. PLoS Genet. 2010 May 20 ;6(5)
  • Corellou F, Schwartz C, Motta JP, Djouani-Tahri el B, Sanchez F, Bouget FY. Clocks in the green lineage : comparative functional analysis of the circadianarchitecture of the picoeukaryote Ostreococcus. Plant Cell. 2009 Nov ;21(11):3436-49.
  • Corellou F and Bouget FY (2008). Expression of polypeptides from the nuclear genome of Ostreococcus sp. US patent PCT/IB2008/000281.

Collaborateurs :
Juliette Jouhet, CNRS Grenoble
Olga Saranova and Richard Haslam, Rothamsted Research, Harpenden, UK
Iwane Suzuki, University of Tsukuba, Japan