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[April 20, 2018] Amélie Bernard participated in the recently published study of the post-transcriptional control of autophagy by XRN1 in collaboration with the Klionsky Lab (Delorme-Axford et al., Autophagy, 2018).
In yeast, deletion of XRN1 enhances autophagy and the frequency of autophagosome formation. Loss of Xrn1 results in the upregulation of autophagy-related (ATG) transcripts under nutrient-replete conditions, and this effect is dependent on the ribonuclease activity of Xrn1. In mammalian cells, siRNA depletion of XRN1 enhances autophagy and the replication of 2 picornaviruses.
Check it out : https://doi.org/10.1080/15548627.2018.1441648